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Tuning the Lewis Basicity of Pyridine: Structural and Theoretical Characterization of the SO₃ Adducts of Pyridine Derivatives

The synthesis and isolation of seven novel Lewis adducts between substituted pyridine derivatives and sulfur trioxide (SO₃) is reported.

Generalized scheme for a py·S₂O₆ adduct, which additionally coordinates free SO₃ units. Bond lengths and distances that are suitable for general comparisons are marked.

In the article published in Inorganic Chemistry Jan Langwald, Mathias Wickleder et al. dive deep into the systematical study by structural analyses and computational studies. The Lewis basicity correlates with the nature of the substituents of the pyridine ring, as can be seen from the S–N distances and the formation of higher SO3 adducts, i.e., further uptake of sulfur trioxide.